A 90-year-old man, with no history of coronary artery disease, diabetes mellitus, hypertension, or hyperlipidemia, was administered 750 mg cefuroxime axetil IM for urinary tract infection. About 10 minutes after the injection, the patient developed chest pain and pruritic skin rashes.6.7/10. Jun 10, 2019 · Off-Label Use of Cefuroxime in Adults include: The Oral Cefuroxime axetil is metabolized in the intestinal mucosa and blood to cefuroxime. 60 minutes, after intravenous injection is 2 – 3 minutes, and after oral administration is 3 – 4 hours.
May 27, 2019 · Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Aug 2019), Cerner Multum™ (updated 1 Aug 2019), 6.7/10. Peak serum levels of cefuroxime after administration of cefuroxime axetil occur within 2 hours following an oral dose. Cefuroxime axetil oral suspension was not bioequivalent to cefuroxime axetil tablets when tested in healthy adults. The tablet and powder for oral suspension formulations are NOT substitutable on a milligram-per-milligram basis.
Cefuroxime axetil is a prodrug of cefuroxime and has little, if any, antibacterial activity until hydrolyzed in vivo to cefuroxime. In this study, the absorption of cefuroxime axetil in the small intestines of anesthetized rats was investigated in situ, by perfusion at four concentrations (11.8, 5, 118 and 200 uM). Absorption: Cefuroxime sodium isn’t well absorbed from the GI tract and must be given parenterally. Cefuroxime axetil is better absorbed orally; between 37% and 52% of an oral dose is absorbed. Food appears to enhance absorption.
Cefuroxime AXetil Tablet is used to treat various type of infections. These include bacterial infections of the skin, urinary tract infections, sexually transmitted infections (uncomplicated gonorrhea) and middle ear infections.Cefuroxime AXetil is also used to treat inflammation of the pharynx or tonsils, maxillary sinuses, and bronchial tubes inside the lungs. Intermittent IV infusions of cefuroxime generally are infused over 15-60 minutes. IM Injection. Results of a study in healthy adults indicate that cefuroxime axetil oral suspensions containing 125 mg/5 mL or 250 mg/5 mL are bioequivalent. In healthy adults who received a 250-mg dose of cefuroxime axetil given as a suspension containing 125.